Nothing Is Undruggable: Frontier Medicines' AI Discovery Engine

About this session

What if the proteins we call "undruggable" simply haven't met the right drug discovery platform and infrastructure? Most disease-relevant proteins are considered undruggable, putting potential therapies for cancer and other diseases out of reach — and while covalent chemistry has long held the potential to unlock them, the field has lacked the data and models to apply it systematically. This talk goes inside the infrastructure Frontier Medicines built to change that: a proprietary data asset spanning seven years and hundreds of millions of measured molecular interactions, and CovalentAI, a suite of covalent-specific models trained on it. You'll learn how experimental profiling reveals binding sites that were previously invisible, how CovalentAI scores and ranks them to assess probability of technical success and shape discovery strategy, and how an MCP-powered agentic layer puts specialist-grade analysis in every scientist's hands. Underlying it all is a durable strategic advantage: the data can't be sourced, only generated over years, so every program makes the next one faster. Join us to see how proprietary experimental data generation & purpose-built AI combine to unlock the undruggable proteome and create a pipeline of potential new medicines for patients.